Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer's disease, frontotemporal dementia and healthy older individuals.

Simple item page
dc.creatorRequena-Komuro, Maï-Carmen
dc.creatorJiang, Jessica
dc.creatorDobson, Lucianne
dc.creatorBenhamou, Elia
dc.creatorRussell, Lucy
dc.creatorBond, Rebecca L
dc.creatorBrotherhood, Emilie V
dc.creatorGreaves, Caroline
dc.creatorBarker, Suzie
dc.creatorRohrer, Jonathan D
dc.creatorCrutch, Sebastian J
dc.creatorWarren, Jason D
dc.creatorHardy, Chris Jd
dc.date2023-01-04T17:36:38Z
dc.date2023-01-04T17:36:38Z
dc.date2022-11-25
dc.date2023-01-04T17:36:38Z
dc.date.accessioned2026-08-03T01:49:32Z
dc.descriptionOBJECTIVES: We explored whether adapting neuropsychological tests for online administration during the COVID-19 pandemic was feasible for dementia research. DESIGN: We used a longitudinal design for healthy controls, who completed face-to-face assessments 3-4 years before remote assessments. For patients, we used a cross-sectional design, contrasting a prospective remote cohort with a retrospective face-to-face cohort matched for age/education/severity. SETTING: Remote assessments were conducted using video-conferencing/online testing platforms, with participants using a personal computer/tablet at home. Face-to-face assessments were conducted in testing rooms at our research centre. PARTICIPANTS: The remote cohort comprised 25 patients (n=8 Alzheimer's disease (AD); n=3 behavioural variant frontotemporal dementia (bvFTD); n=4 semantic dementia (SD); n=5 progressive non-fluent aphasia (PNFA); n=5 logopenic aphasia (LPA)). The face-to-face patient cohort comprised 64 patients (n=25 AD; n=12 bvFTD; n=9 SD; n=12 PNFA; n=6 LPA). Ten controls who previously participated in face-to-face research also took part remotely. OUTCOME MEASURES: The outcome measures comprised the strength of evidence under a Bayesian framework for differences in performances between testing environments on general neuropsychological and neurolinguistic measures. RESULTS: There was substantial evidence suggesting no difference across environments in both the healthy control and combined patient cohorts (including measures of working memory, single-word comprehension, arithmetic and naming; Bayes Factors (BF)01 >3), in the healthy control group alone (including measures of letter/category fluency, semantic knowledge and bisyllabic word repetition; all BF01 >3), and in the combined patient cohort alone (including measures of working memory, episodic memory, short-term verbal memory, visual perception, non-word reading, sentence comprehension and bisyllabic/trisyllabic word repetition; all BF01 >3). In the control cohort alone, there was substantial evidence in support of a difference across environments for tests of visual perception (BF01=0.0404) and monosyllabic word repetition (BF01=0.0487). CONCLUSIONS: Our findings suggest that remote delivery of neuropsychological tests for dementia research is feasible.
dc.formatapplication/pdf
dc.identifier2044-6055
dc.identifier36428012
dc.identifierPMC9702828
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/344866
dc.identifier10.17863/CAM.92291
dc.identifier2044-6055
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/160108
dc.languageeng
dc.languageeng
dc.publisherBMJ
dc.publisherhttps://doi.org/10.1136/bmjopen-2022-064576
dc.rightsAttribution 4.0 International
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2044-6055
dc.sourcenlmid: 101552874
dc.subjectAdult neurology
dc.subjectDementia
dc.subjectTelemedicine
dc.subjectHumans
dc.subjectFrontotemporal Dementia
dc.subjectAlzheimer Disease
dc.subjectBayes Theorem
dc.subjectCross-Sectional Studies
dc.subjectRetrospective Studies
dc.subjectPandemics
dc.subjectProspective Studies
dc.subjectCOVID-19
dc.subjectNeuropsychological Tests
dc.subjectAphasia
dc.titleRemote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer's disease, frontotemporal dementia and healthy older individuals.
dc.typeArticle

Files

Collections

University of Cambridge Apollo