PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway

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dc.creatorPotuschak, Thomas
dc.creatorStary, Susanne
dc.creatorSchlögelhofer, Peter
dc.creatorBecker, Frank
dc.creatorNejinskaia, Victoria
dc.creatorBachmair, Andreas
dc.date1998-07-07
dc.date.accessioned2026-08-02T20:20:00Z
dc.descriptionMutants in the PRT1 gene of Arabidopsis thaliana are impaired in the degradation of a normally short-lived intracellular protein that contains a destabilizing N-terminal residue. Proteins bearing such residues are the substrates of an ubiquitin-dependent proteolytic system called the N-end rule pathway. The chromosomal position of PRT1 was determined, and the PRT1 gene was isolated by map-based cloning. The 45-kDa PRT1 protein contains two RING finger domains and one ZZ domain. No other proteins in databases match these characteristics of PRT1. There is, however, a weak similarity to Rad18p of Saccharomyces cerevisiae. The RING finger domains have been found in a number of other proteins that are involved in ubiquitin conjugation, consistent with the proposed role of PRT1 in the plant N-end rule pathway.
dc.identifierhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20902/
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/9653113/
dc.identifierhttps://doi.org/10.1073/pnas.95.14.7904
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/85620
dc.languageen
dc.publisherNational Academy of Sciences
dc.rightsCopyright © 1998, The National Academy of Sciences
dc.sourceProc Natl Acad Sci U S A
dc.subjectBiological Sciences
dc.titlePRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway
dc.typeText

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