Presentation and management of female breast cancer in Egypt

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dc.coverageCairo
dc.creatorYousri Rostom
dc.creatorSalah-Eldin Abdelmoneim
dc.creatorMarwa Shaker
dc.creatorNayera Mahmoud
dc.date2023-05-13T13:50:20Z
dc.date2023-05-13T13:50:20Z
dc.date2022-10-01
dc.date.accessioned2026-08-03T07:43:30Z
dc.descriptionBackground: There have been system inefficiencies in the profiling and management of female breast cancer in Alexandria, Egypt. Aims: To identify barriers to full implementation of international guidelines for the management of female breast cancer patients. Methods: Female breast cancer data were extracted from records of 3 public oncology services in Alexandria, Egypt, from 2007 to 2016 and analysed. Results: A total of 5236 of the available 7125 records were usable. Median age of the patients was 54 years, and the median duration of pre-diagnosis complaint was 3.1 months. Some 522 (31.5%) of the patients had a family history of cancer. For tumour stage, 2527 (55.2%) were early, 1717 (37.6%) were locally advanced, and 331 (7.2%) were at stage IV. Estrogen receptor, progesterone receptor, and HER2 were positive in 3869 (85%), 3545 (78%), and 461 (15.3%) patients, respectively. Chemotherapy started after a median 1.03 months. Adjuvant chemotherapy was given to 3667 (91.7 %) patients and neoadjuvant chemotherapy to 333 (8.3%); 3686 (92.1%) received anthracycline-based combination chemotherapy, and 3613 (86%) received hormonal treatment. One hundred and eighty of 317 eligible patients received Trastuzumab. Local and/or distant recurrence was seen in 1109 (21.2%) patients. In nonmetastatic cases, median overall and disease-free survival were 149.1 and 77.1 months, respectively. In metastatic cases, median progression-free survival was 19.6 months. Conclusion: We observed defects in the record system, there was delay in diagnosis and treatment, and nonadherence to targeted therapy in many patients. Strengthening of national and hospital-based registries is needed in Alexandria, Egypt, with a robust patient navigation system and targeted information, education and communication strategies. Continuous outcomes monitoring and adaptation to implementation needs should be sustained.
dc.description725
dc.description732
dc.formatapplication/pdf
dc.identifier1020-3397
dc.identifier1687-1634 (online)
dc.identifierhttps://iris.who.int/handle/10665/367752
dc.identifierhttps://doi.org/10.26719/emhj.22.076
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/218265
dc.languageEnglish
dc.languageen
dc.publisherWorld Health Organization. Regional Office for the Eastern Mediterranean
dc.relationEastern Mediterranean Health Journal
dc.relation10
dc.relation28
dc.rightsCC BY-NC-SA 3.0 IGO
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/3.0/igo
dc.rightsWorld Health Organization
dc.subjectNoncommunicable Diseases
dc.subjectBreast Neoplasms
dc.subjectEgypt
dc.subjectdiagnosis
dc.subjecttherapy
dc.subjectepidemiology
dc.titlePresentation and management of female breast cancer in Egypt
dc.typeJournal articles

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