Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies.

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dc.creatorLarson, Peder Ez
dc.creatorBernard, Jenna Ml
dc.creatorBankson, James A
dc.creatorBøgh, Nikolaj
dc.creatorBok, Robert A
dc.creatorChen, Albert P
dc.creatorCunningham, Charles H
dc.creatorGordon, Jeremy
dc.creatorHövener, Jan-Bernd
dc.creatorLaustsen, Christoffer
dc.creatorMayer, Dirk
dc.creatorMcLean, Mary A
dc.creatorSchilling, Franz
dc.creatorSlater, James
dc.creatorVanderheyden, Jean-Luc
dc.creatorvon Morze, Cornelius
dc.creatorVigneron, Daniel B
dc.creatorXu, Duan
dc.creatorHP 13C MRI Consensus Group
dc.date2023-09-06T23:31:00Z
dc.date2023-09-06T23:31:00Z
dc.date2023-11-22
dc.date.accessioned2026-08-03T03:50:31Z
dc.descriptionMRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of hyperpolarized agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-13C]pyruvate - by far the most commonly used agent, which sits at a key metabolic junction in glycolysis. The paper is divided into four major topic areas: (1) HP 13C-pyruvate preparation, (2) MRI system setup and calibrations, (3) data acquisition and image reconstruction, and (4) data analysis and quantification. In each area, we identified the key components for a successful study, summarized both published studies and current practices, and discuss evidence gaps, strengths, and limitations. This paper is the output of the "HP 13C MRI Consensus Group" as well as the ISMRM Hyperpolarized Media MR and Hyperpolarized Methods & Equipment study groups. It further aims to provide a comprehensive reference for future consensus building as the field continues to advance human studies with this metabolic imaging modality.
dc.formatapplication/pdf
dc.identifier0740-3194
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/356811
dc.identifierhttps://doi.org/10.17863/CAM.101475
dc.identifier2331-8422
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/181479
dc.languageeng
dc.publisherWiley
dc.publisherDepartment of Radiology
dc.rightsAttribution 4.0 International
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectHyperpolarized MRI
dc.subjectcarbon-13
dc.subjectdissolution dynamic nuclear polarization
dc.subjectmetabolic imaging
dc.subjectpyruvate
dc.titleCurrent Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies.
dc.typeArticle

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