The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene.
| dc.creator | Sureau, A | |
| dc.creator | Soret, J | |
| dc.creator | Vellard, M | |
| dc.creator | Crochet, J | |
| dc.creator | Perbal, B | |
| dc.date | 1992-12-15 | |
| dc.date.accessioned | 2026-08-03T01:50:36Z | |
| dc.description | We have previously reported that expression of the c-myb gene in normal avian thymic cells proceeds through the intermolecular recombination of ET (thymus-specific) and c-myb coding sequences, thereby generating a novel type of c-myb product. Antisense transcripts expressed from the ET locus encode the extremely well-conserved splicing factor PR264/SC35. We now show that the human PR264 promoter sequences contain several myb-recognition elements that efficiently interact in vitro with the c-myb DNA-binding domain. Moreover, expression from the PR264 promoter is transactivated, both in vitro and in cultured cells, by different c-myb products. Thus, the PR264 gene is most likely a physiological target for the c-myb family of transcription factors. IMAGES: | |
| dc.identifier | https://pmc.ncbi.nlm.nih.gov/articles/PMC50620/ | |
| dc.identifier | https://pubmed.ncbi.nlm.nih.gov/1465383/ | |
| dc.identifier | https://doi.org/10.1073/pnas.89.24.11683 | |
| dc.identifier.uri | https://repo.dare.co.zw/handle/123456789/160383 | |
| dc.language | en | |
| dc.publisher | National Academy of Sciences | |
| dc.source | Proc Natl Acad Sci U S A | |
| dc.subject | Research Article | |
| dc.title | The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene. | |
| dc.type | Text |