In differentiated CD4(+) T Cells, interleukin 4 production is cytokine-autonomous, whereas interferon γ production is cytokine-dependent
| dc.creator | Hu-Li, Jane | |
| dc.creator | Huang, Hua | |
| dc.creator | Ryan, John | |
| dc.creator | Paul, William E. | |
| dc.date | 1997-04-01 | |
| dc.date.accessioned | 2026-08-02T20:13:42Z | |
| dc.description | CD4(+) T cells from T cell receptor transgenic mice that have been vigorously primed to be interleukin (IL)-4 producers (T(H2) cells) are capable of producing IL-4 even if restimulated in the absence of IL-4 and in the presence of IL-12. T cells vigorously primed in the absence of IL-4 (T(H1) cells) fail to produce IL-4 even if restimulated under conditions that would cause a naive T cell to produce IL-4. In contrast, interferon γ (IFN-γ) production is highly cytokine-regulated. T cells primed in the presence of IL-4 develop into IFN-γ producers if IFN-γ is included in the priming culture and if the cells are challenged in the presence of IL-12, presumably reflecting the role of IFN-γ in inducing responsiveness to IL-12. Cells primed in the absence of IL-4 become highly responsive to IL-12 if IFN-γ is included in the priming culture, and these cells are excellent IFN-γ producers upon challenge; IL-12 considerably enhances their production of IFN-γ. If cells are primed in the absence of IL-4 and IFN-γ, they show very weak responsiveness to IL-12 as determined by STAT-4 activation. However, these cells acquire IL-12 responsiveness if cultured with IFN-γ for a period as short as 4 hr. Thereafter, they produce large amounts of IFN-γ upon challenge with antigen in the presence of IL-12. These results indicate that in primed CD4(+) T cells, IL-4 production is largely cytokine-autonomous, whereas IFN-γ production is highly cytokine-regulated. | |
| dc.identifier | https://pmc.ncbi.nlm.nih.gov/articles/PMC20344/ | |
| dc.identifier | https://pubmed.ncbi.nlm.nih.gov/9096368/ | |
| dc.identifier | https://doi.org/10.1073/pnas.94.7.3189 | |
| dc.identifier.uri | https://repo.dare.co.zw/handle/123456789/84183 | |
| dc.language | en | |
| dc.publisher | National Academy of Sciences | |
| dc.source | Proc Natl Acad Sci U S A | |
| dc.subject | Biological Sciences | |
| dc.title | In differentiated CD4(+) T Cells, interleukin 4 production is cytokine-autonomous, whereas interferon γ production is cytokine-dependent | |
| dc.type | Text |