The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects.

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dc.creatorCupaioli, Francesca A
dc.creatorZucca, Fabio A
dc.creatorCaporale, Cinzia
dc.creatorLesch, Klaus-Peter
dc.creatorPassamonti, Luca
dc.creatorZecca, Luigi
dc.date2020-08-17T23:30:38Z
dc.date2020-08-17T23:30:38Z
dc.date2021-03-02
dc.date.accessioned2026-08-03T04:37:46Z
dc.descriptionIn modern societies, there is a strive to improve the quality of life related to risk of crimes which inevitably requires a better understanding of brain determinants and mediators of aggression. Neurobiology provides powerful tools to achieve this end. Pre-clinical and clinical studies show that changes in regional volumes, metabolism-function and connectivity within specific neural networks are related to aggression. Subregions of prefrontal cortex, insula, amygdala, basal ganglia and hippocampus play a major role within these circuits and have been consistently implicated in biology of aggression. Genetic variations in proteins regulating the synthesis, degradation, and transport of serotonin and dopamine as well as their signal transduction have been found to mediate behavioral variability observed in aggression. Gene-gene and gene-environment interactions represent additional important risk factors for aggressiveness. Considering the social burden of pathological forms of aggression, more basic and translational studies should be conducted to accelerate applications to clinical practice, justice courts, and policy making.
dc.formatPrint-Electronic
dc.formatapplication/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.identifier0278-5846
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/309298
dc.identifier10.17863/CAM.56396
dc.identifier1878-4216
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/191780
dc.languageeng
dc.languageeng
dc.publisherElsevier
dc.publisherhttps://doi.org/10.1016/j.pnpbp.2020.110059
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAggression
dc.subjectbrain regions of aggression
dc.subjectdopamine and serotonin in aggression
dc.subjectgenetics of aggression
dc.subjectimaging of aggressive brain
dc.subjectAggression
dc.subjectBrain
dc.subjectBrain Chemistry
dc.subjectDopamine
dc.subjectGene-Environment Interaction
dc.subjectHumans
dc.subjectNeuroimaging
dc.subjectSerotonin
dc.titleThe neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects.
dc.typeArticle

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