Receptor-mediated activation of a plant Ca(2+)-permeable ion channel involved in pathogen defense

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dc.creatorZimmermann, Sabine
dc.creatorNürnberger, Thorsten
dc.creatorFrachisse, Jean-Marie
dc.creatorWirtz, Wolfgang
dc.creatorGuern, Jean
dc.creatorHedrich, Rainer
dc.creatorScheel, Dierk
dc.date1997-03-18
dc.date.accessioned2026-08-02T20:11:20Z
dc.descriptionPathogen recognition at the plant cell surface typically results in the initiation of a multicomponent defense response. Transient influx of Ca(2+) across the plasma membrane is postulated to be part of the signaling chain leading to pathogen resistance. Patch-clamp analysis of parsley protoplasts revealed a novel Ca(2+)-permeable, La(3+)-sensitive plasma membrane ion channel of large conductance (309 pS in 240 mM CaCl(2)). At an extracellular Ca(2+) concentration of 1 mM, which is representative of the plant cell apoplast, unitary channel conductance was determined to be 80 pS. This ion channel (LEAC, for large conductance elicitor-activated ion channel) is reversibly activated upon treatment of parsley protoplasts with an oligopeptide elicitor derived from a cell wall protein of Phytophthora sojae. Structural features of the elicitor found previously to be essential for receptor binding, induction of defense-related gene expression, and phytoalexin formation are identical to those required for activation of LEAC. Thus, receptor-mediated stimulation of this channel appears to be causally involved in the signaling cascade triggering pathogen defense in parsley.
dc.identifierhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20162/
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/11038609/
dc.identifierhttps://doi.org/10.1073/pnas.94.6.2751
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/83599
dc.languageen
dc.publisherNational Academy of Sciences
dc.rightsCopyright © 1997, The National Academy of Sciences of the USA
dc.sourceProc Natl Acad Sci U S A
dc.subjectBiological Sciences
dc.titleReceptor-mediated activation of a plant Ca(2+)-permeable ion channel involved in pathogen defense
dc.typeText

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