The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.
| dc.creator | Prochazka, M | |
| dc.creator | Gaskins, H R | |
| dc.creator | Shultz, L D | |
| dc.creator | Leiter, E H | |
| dc.date | 1992-04-15 | |
| dc.date.accessioned | 2026-08-03T01:32:07Z | |
| dc.description | Homozygosity for the severe combined immunodeficiency (scid) mutation results in a block in T- and B-lymphocyte development. An unusually high incidence of spontaneous thymic lymphoma development was observed after transfer of this mutation from the C.B-17 congenic strain background onto the diabetes-susceptible nonobese diabetic (NOD) background. Thymomagenesis in the NOD-scid/scid mouse was associated with expression of an NOD mouse-unique endogenous ecotropic murine leukemia provirus locus (Emv-30, mapped to proximal region of chromosome 11) not expressed in the standard substrain NOD/Lt thymus. All tumors exhibited insertions of ecotropic proviruses, whereas only a subset also exhibited proviral integrations of mink cell focus-forming retrovirus. Neither class of retrovirus was associated with consistent integration into genes previously associated with activation of oncogenesis. We propose that the unusual features of T-cell ontogeny characteristic of the NOD inbred strain synergize with the scid-imparted block in thymocyte development, leading to activation of the NOD-unique Emv-30 to initiate thymomagenesis. IMAGES: | |
| dc.identifier | https://pmc.ncbi.nlm.nih.gov/articles/PMC48852/ | |
| dc.identifier | https://pubmed.ncbi.nlm.nih.gov/1373493/ | |
| dc.identifier | https://doi.org/10.1073/pnas.89.8.3290 | |
| dc.identifier.uri | https://repo.dare.co.zw/handle/123456789/155414 | |
| dc.language | en | |
| dc.publisher | National Academy of Sciences | |
| dc.source | Proc Natl Acad Sci U S A | |
| dc.subject | Research Article | |
| dc.title | The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. | |
| dc.type | Text |