Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach - 2010 revision
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World Health Organization
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145 p.
This guideline provides updated WHO recommendations on antiretroviral therapy (ART) for adults and adolescents living with HIV within a public health framework, with particular emphasis on settings with limited health system capacity and resources. Developed in accordance with the WHO Guidelines Review Committee process and informed by GRADE evidence profiles, systematic reviews, risk–benefit analyses, consultations with people living with HIV, and assessments of feasibility and cost, it updates previous WHO guidance in light of emerging evidence on the optimal timing of ART initiation, preferred treatment regimens, the management of treatment failure, and HIV coinfection with tuberculosis and chronic viral hepatitis. The publication is intended to support national treatment advisory boards, programme managers and partners responsible for implementing HIV care and treatment programmes. The guideline presents evidence-based recommendations on when to initiate ART, preferred first-, second- and third-line antiretroviral regimens, laboratory monitoring, management of HIV/TB and HIV/HBV coinfection, treatment switching criteria, and package-of-care interventions. It also outlines the methodology underpinning the recommendations, emphasizing transparent evidence appraisal, public health principles, and country adaptation according to epidemiological context, health system capacity and available resources. The guidance promotes earlier HIV diagnosis and treatment, the use of less toxic antiretroviral regimens, strategic laboratory monitoring, and sustainable implementation to improve access to high-quality HIV care and treatment.
This guideline provides updated WHO recommendations on antiretroviral therapy (ART) for adults and adolescents living with HIV within a public health framework, with particular emphasis on settings with limited health system capacity and resources. Developed in accordance with the WHO Guidelines Review Committee process and informed by GRADE evidence profiles, systematic reviews, risk–benefit analyses, consultations with people living with HIV, and assessments of feasibility and cost, it updates previous WHO guidance in light of emerging evidence on the optimal timing of ART initiation, preferred treatment regimens, the management of treatment failure, and HIV coinfection with tuberculosis and chronic viral hepatitis. The publication is intended to support national treatment advisory boards, programme managers and partners responsible for implementing HIV care and treatment programmes. The guideline presents evidence-based recommendations on when to initiate ART, preferred first-, second- and third-line antiretroviral regimens, laboratory monitoring, management of HIV/TB and HIV/HBV coinfection, treatment switching criteria, and package-of-care interventions. It also outlines the methodology underpinning the recommendations, emphasizing transparent evidence appraisal, public health principles, and country adaptation according to epidemiological context, health system capacity and available resources. The guidance promotes earlier HIV diagnosis and treatment, the use of less toxic antiretroviral regimens, strategic laboratory monitoring, and sustainable implementation to improve access to high-quality HIV care and treatment.