The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders.

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dc.creatorBayraktar, Gonca
dc.creatorKreutz, Michael R
dc.date2018-11-07T00:30:35Z
dc.date2018-11-07T00:30:35Z
dc.date2018
dc.date.accessioned2026-08-03T04:06:33Z
dc.descriptionOver the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
dc.formatElectronic-eCollection
dc.formatapplication/pdf
dc.identifier1662-5099
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/284685
dc.identifier10.17863/CAM.32058
dc.identifier1662-5099
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/185046
dc.languageeng
dc.languageeng
dc.publisherFrontiers
dc.publisherhttps://doi.org/10.3389/fnmol.2018.00169
dc.rightsAttribution 4.0 International
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectDNA Methylation
dc.subjectGADD45B
dc.subjectTET enzymes
dc.subjectbase excision repair (BER)
dc.subjectgene expression
dc.subjectneural disorders
dc.subjectneurons
dc.subjectsynaptic plasticity
dc.titleThe Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders.
dc.typeArticle

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