WHO guidelines for the treatment of patients with cystic echinococcosis: web annex A: evidence synthesis summary
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World Health Organization
Abstract
Description
iv, 58 p.
This web annex to the WHO guidelines for the treatment of patients with cystic echinococcosis presents the evidence synthesis undertaken to support recommendations on the management of uncomplicated hepatic and pulmonary cystic echinococcosis. The document describes the methodology used to identify, appraise and synthesize available evidence, including literature searches, PICO-based research questions, risk-of-bias assessment and application of the GRADE approach. Evidence from randomized controlled trials and prospective comparative studies was analysed to compare different therapeutic approaches, including albendazole, PAIR, surgery, standard catheterization techniques and related interventions. The publication summarizes findings on treatment effectiveness, recurrence, complications, symptom improvement and duration of hospital admission across different cyst stages and treatment settings. Evidence was generally limited, with few eligible studies, small sample sizes and low or very low certainty ratings for most outcomes. In situations where research evidence was lacking, expert consensus and observational evidence informed the guideline development process. The annex also includes detailed descriptions of included studies, meta-analyses, risk-of-bias summaries, search strategies and ongoing studies relevant to the treatment of cystic echinococcosis.
This web annex to the WHO guidelines for the treatment of patients with cystic echinococcosis presents the evidence synthesis undertaken to support recommendations on the management of uncomplicated hepatic and pulmonary cystic echinococcosis. The document describes the methodology used to identify, appraise and synthesize available evidence, including literature searches, PICO-based research questions, risk-of-bias assessment and application of the GRADE approach. Evidence from randomized controlled trials and prospective comparative studies was analysed to compare different therapeutic approaches, including albendazole, PAIR, surgery, standard catheterization techniques and related interventions. The publication summarizes findings on treatment effectiveness, recurrence, complications, symptom improvement and duration of hospital admission across different cyst stages and treatment settings. Evidence was generally limited, with few eligible studies, small sample sizes and low or very low certainty ratings for most outcomes. In situations where research evidence was lacking, expert consensus and observational evidence informed the guideline development process. The annex also includes detailed descriptions of included studies, meta-analyses, risk-of-bias summaries, search strategies and ongoing studies relevant to the treatment of cystic echinococcosis.
Keywords
Echinococcosis, Hepatic, Echinococcosis, Pulmonary, Echinococcosis, Liver, Cysts, Lung, Anthelmintics, Praziquantel, Albendazole, Surgical Procedures, Operative, Catheterization, Laparoscopy, Punctures, Evidence-Based Medicine, Risk Assessment, Systematic Reviews as Topic, Treatment Outcome, Patient Preference, Bias, GRADE Approach, Guidelines as Topic, drug therapy, therapeutic use, methods