Cognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice.

Simple item page
dc.creatorXu, Shu Ping
dc.creatorYang, Yan Yan
dc.creatorXue, Dan
dc.creatorLiu, Jin Xiu
dc.creatorLiu, Xin Min
dc.creatorFan, Tai-Ping
dc.creatorle Pan, Rui
dc.creatorLi, Pengtao
dc.date2020-07-21T23:30:29Z
dc.date2020-07-21T23:30:29Z
dc.date2011-01
dc.date.accessioned2026-08-03T04:03:00Z
dc.descriptionPolygalasaponins are the major active constituents of Polygala tenuifolia exhibiting antiamnesic activity, but their applications are limited due to their toxicities. Evidence showed that the toxicities can be attenuated by hydrolysis. Herein, effects of a hydrolysate of polygalasaponins (HPS) on cognitive impairment induced by Aβ25−35 were assessed by Morris water maze and step-through passive avoidance tests. The impaired spatial reference memory was improved by HPS (50 and 100mg/kg). In the acquisition trial of step-through test, HPS (50 and 100mg/kg) increased the latency into the dark chamber and decreased the error frequency significantly (P < .05). However, no significant change was observed during the retention trial. Additionally, HPS increased the corresponding SOD activities (62.34%, 22.09%) and decreased MDA levels (28.21%, 32.35%) in both cortex and hippocampus as compared to model animals. These results show that HPS may be a useful treatment against amnesia probably via its antioxidant properties.
dc.formatPrint-Electronic
dc.formatapplication/pdf
dc.identifier1741-427X
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/308225
dc.identifier10.17863/CAM.55315
dc.identifier1741-4288
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/184272
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.titleCognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice.
dc.typeArticle

Files

Collections

University of Cambridge Apollo