LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.
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Springer Nature
https://doi.org/10.1007/s00251-016-0924-z
https://doi.org/10.1007/s00251-016-0924-z
Abstract
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Leukocyte immunoglobulin-like receptors (LILR) are expressed mostly on myelomonocytic cells where they are mediators of immunological tolerance. Two LILR genes, LILRA3 and LILRA6, exhibit marked copy number variation. We assessed the contribution of these genes to atopic dermatitis (AD) by analysing transmission in 378 AD families. The data indicated that copies of LILRA6 were over-transmitted to affected patients. They are consistent with a contribution of LILR genes to AD. They could affect the equilibrium between activating and inhibitory signals in the immune response.
This work was funded by the Medical Research Council (MRC) and Association for International Cancer Research (AICR) with additional support from the Wellcome Trust and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. María Rocío López-Álvarez was funded by Ministerio de Educación of Spain, under the programme "Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I-D+i 2008-2011" and Fundación Séneca 04087/GERM/06 Project.
This is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00251-016-0924-z
This work was funded by the Medical Research Council (MRC) and Association for International Cancer Research (AICR) with additional support from the Wellcome Trust and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. María Rocío López-Álvarez was funded by Ministerio de Educación of Spain, under the programme "Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I-D+i 2008-2011" and Fundación Séneca 04087/GERM/06 Project.
This is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00251-016-0924-z