The third gamma subunit of the gamma-aminobutyric acid type A receptor family.

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dc.creatorHerb, A
dc.creatorWisden, W
dc.creatorLüddens, H
dc.creatorPuia, G
dc.creatorVicini, S
dc.creatorSeeburg, P H
dc.date1992-02-15
dc.date.accessioned2026-08-03T01:27:30Z
dc.descriptionCloned cDNAs encoding a member of the gamma-aminobutyric acid type A receptor gamma-subunit class were isolated from rat-brain-mRNA-derived libraries. The gamma 3 mRNA is present in cortex, claustrum, caudate putamen, and some thalamic nuclei, particularly the medial geniculate nucleus, where it is the predominant gamma-subunit transcript. The gamma 3 gene is expressed at very low levels in cerebellum and hippocampus. In coexpression experiments with the alpha 1 and beta 2 subunits, gamma 3 imparts benzodiazepine binding to gamma-aminobutyric acid type A receptors and forms gamma-aminobutyric acid-gated benzodiazepine-modulated chloride channels that exhibit a larger conductance than alpha 1 beta 2 receptor channels. Furthermore, the presence of gamma 3 in place of gamma 2 in alpha 1 beta 2 gamma x receptors generates a marked decrease in the affinity of agonists while leaving the affinity of antagonists or negative modulators largely unaffected. IMAGES:
dc.identifierhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48465/
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/1311098/
dc.identifierhttps://doi.org/10.1073/pnas.89.4.1433
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/154197
dc.languageen
dc.publisherNational Academy of Sciences
dc.sourceProc Natl Acad Sci U S A
dc.subjectResearch Article
dc.titleThe third gamma subunit of the gamma-aminobutyric acid type A receptor family.
dc.typeText

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