Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency.
| dc.creator | Gupta, S | |
| dc.creator | Ribak, C E | |
| dc.creator | Gollapudi, S | |
| dc.creator | Kim, C H | |
| dc.creator | Salahuddin, S Z | |
| dc.date | 1992-08-15 | |
| dc.date.accessioned | 2026-08-03T01:41:09Z | |
| dc.description | A number of non-human-immunodeficiency-virus (HIV) type 1 disorders are associated with CD4+ T-cell deficiency and dysfunction. However, the etiopathogenesis of CD4+ T-cell immunodeficiency in these disease states remains unclear. Human intracisternal retroviral (HICRV) particles were detected in a lymphoblastoid cell line exposed to mononuclear cells from a patient with severe CD4+ T-cell deficiency without risk factors for HIV infection. Ultrastructurally, the HICRV is distinct from HIV-1, HIV-2, human T-lymphotropic virus (HTLV) type I, and HTLV-II. Supernatants of activated mononuclear cells showed significant reverse transcriptase activity that was predominantly Mn2+ dependent. The patient's mononuclear cells were negative for HIV-1, HIV-2, HTLV-I, and HTLV-II proviruses as demonstrated by the lack of amplification by PCR. Also, the patient's serum was negative for antibodies to HIV-1, HTLV-I, and HTLV-II and for HIV-1 p24 antigen; however, serum was positive for antibodies against the HICRV as demonstrated by Western blot. Similar HICRV particles were detected in a lymphoblastoid cell line exposed to mononuclear cells from the patient's daughter, who showed CD4+ T-cell dysfunction. The HICRV may be associated with CD4+ T-cell immunodeficiency and dysfunction in patients without risk for HIV-1, HIV-2, HTLV-I, and HTLV-II. IMAGES: | |
| dc.identifier | https://pmc.ncbi.nlm.nih.gov/articles/PMC49805/ | |
| dc.identifier | https://pubmed.ncbi.nlm.nih.gov/1380169/ | |
| dc.identifier | https://doi.org/10.1073/pnas.89.16.7831 | |
| dc.identifier.uri | https://repo.dare.co.zw/handle/123456789/157840 | |
| dc.language | en | |
| dc.publisher | National Academy of Sciences | |
| dc.source | Proc Natl Acad Sci U S A | |
| dc.subject | Research Article | |
| dc.title | Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency. | |
| dc.type | Text |