Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids.

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dc.creatorPark, Yoonseok
dc.creatorFranz, Colin K
dc.creatorRyu, Hanjun
dc.creatorLuan, Haiwen
dc.creatorCotton, Kristen Y
dc.creatorKim, Jong Uk
dc.creatorChung, Ted S
dc.creatorZhao, Shiwei
dc.creatorVazquez-Guardado, Abraham
dc.creatorYang, Da Som
dc.creatorLi, Kan
dc.creatorAvila, Raudel
dc.creatorPhillips, Jack K
dc.creatorQuezada, Maria J
dc.creatorJang, Hokyung
dc.creatorKwak, Sung Soo
dc.creatorWon, Sang Min
dc.creatorKwon, Kyeongha
dc.creatorJeong, Hyoyoung
dc.creatorBandodkar, Amay J
dc.creatorHan, Mengdi
dc.creatorZhao, Hangbo
dc.creatorOsher, Gabrielle R
dc.creatorWang, Heling
dc.creatorLee, KunHyuck
dc.creatorZhang, Yihui
dc.creatorHuang, Yonggang
dc.creatorFinan, John D
dc.creatorRogers, John A
dc.date2021-04-19T23:30:29Z
dc.date2021-04-19T23:30:29Z
dc.date2021-03
dc.date.accessioned2026-08-03T04:06:20Z
dc.descriptionThree-dimensional (3D), submillimeter-scale constructs of neural cells, known as cortical spheroids, are of rapidly growing importance in biological research because these systems reproduce complex features of the brain in vitro. Despite their great potential for studies of neurodevelopment and neurological disease modeling, 3D living objects cannot be studied easily using conventional approaches to neuromodulation, sensing, and manipulation. Here, we introduce classes of microfabricated 3D frameworks as compliant, multifunctional neural interfaces to spheroids and to assembloids. Electrical, optical, chemical, and thermal interfaces to cortical spheroids demonstrate some of the capabilities. Complex architectures and high-resolution features highlight the design versatility. Detailed studies of the spreading of coordinated bursting events across the surface of an isolated cortical spheroid and of the cascade of processes associated with formation and regrowth of bridging tissues across a pair of such spheroids represent two of the many opportunities in basic neuroscience research enabled by these platforms.
dc.formatElectronic-Print
dc.formatapplication/pdf
dc.identifier2375-2548
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/321281
dc.identifier10.17863/CAM.68405
dc.identifier2375-2548
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/185001
dc.languageeng
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.publisherhttps://doi.org/10.1126/sciadv.abf9153
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightshttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectNervous System
dc.subjectNeurons
dc.titleThree-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids.
dc.typeArticle

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