A One Health approach to understanding and managing Nipah virus outbreaks.

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dc.creatorYadav, Pragya D
dc.creatorBaid, Kaushal
dc.creatorPatil, Deepak Y
dc.creatorShirin, Tahmina
dc.creatorRahman, Mohammed Ziaur
dc.creatorPeel, Alison J
dc.creatorEpstein, Jonathan H
dc.creatorMontgomery, Joel M
dc.creatorPlowright, Raina K
dc.creatorSalje, Henrik
dc.creatorGurley, Emily S
dc.creatorSatter, Syed M
dc.creatorBanerjee, Arinjay
dc.date2025-07-10T23:30:21Z
dc.date2025-06
dc.date.accessioned2026-08-03T01:34:30Z
dc.descriptionNipah virus (NiV) is a zoonotic paramyxovirus belonging to the genus Henipavirus, which infects Pteropus bat species in Southeast and South Asia. Since its discovery in the late 1990s in Malaysia, NiV has caused outbreaks in humans in Singapore, Bangladesh, India and the Philippines. The spillover pathway for the most recent NiV outbreak in 2023 in Kerala, India, remains speculative. NiV causes serious disease in infected humans, with a mean case-fatality rate of 70%, and no approved treatment or vaccines exist. Humans have been infected directly from bats through shared food or through infected bridging hosts, including pigs and horses, although other spillover pathways may exist. Here, we review the pathways of NiV spillover and transmission, highlighting areas needing further research. We emphasize the importance of collaborative and multidisciplinary efforts both in the laboratory and in the field, and the implementation of a One Health strategy to prevent future epidemics.
dc.formatPrint-Electronic
dc.formatapplication/pdf
dc.identifier2058-5276
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/386681
dc.identifierhttps://doi.org/10.17863/CAM.119797
dc.identifier2058-5276
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/156084
dc.languageeng
dc.publisherSpringer Nature
dc.publisherDepartment of Genetics
dc.publisherhttps://doi.org/10.1038/s41564-025-02020-9
dc.rightsAttribution 4.0 International
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectHenipavirus Infections
dc.subjectNipah Virus
dc.subjectAnimals
dc.subjectHumans
dc.subjectDisease Outbreaks
dc.subjectChiroptera
dc.subjectOne Health
dc.subjectZoonoses
dc.subjectSwine
dc.subjectViral Zoonoses
dc.subjectHorses
dc.titleA One Health approach to understanding and managing Nipah virus outbreaks.
dc.typeArticle

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