The animal models for dengue virus infection.
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WHO Regional Office for South-East Asia
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Dengue Bulletin. 2004 Dec; 28: 168-173.
Currently, the mechanisms involved in the pathogenesis of DHF/DSS remain poorly understood and there is no effective vaccine available to prevent infection with DEN virus. The lack of a reliable small animal model that mimics dengue disease is a major obstacle. In this paper, the development of small animal models such as mice for dengue virus infections is reviewed.
Currently, the mechanisms involved in the pathogenesis of DHF/DSS remain poorly understood and there is no effective vaccine available to prevent infection with DEN virus. The lack of a reliable small animal model that mimics dengue disease is a major obstacle. In this paper, the development of small animal models such as mice for dengue virus infections is reviewed.