Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study.

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dc.creatorBanim, Paul Jr
dc.creatorLuben, Robert
dc.creatorKhaw, Kay-Tee
dc.creatorHart, Andrew R
dc.date2018-09-21T15:21:13Z
dc.date2018-09-21T15:21:13Z
dc.date2018-09
dc.date.accessioned2026-08-03T01:45:21Z
dc.descriptionBACKGROUND: Dietary oleic acid may prevent pancreatic ductal adenocarcinoma (PDA) by reducing hyperinsulinaemia which can otherwise promote DNA damage and tumour growth. Results from previous epidemiological studies investigating oleic acid are inconsistent. This study aims to clarify the relationship between dietary oleic acid intake and the risk of developing PDA using nutritional information from food diaries plus published serum biomarker data from HbA1c. METHODS: 23,658 participants, aged 40-74 years, were recruited into EPIC-Norfolk and completed 7-day food diaries which recorded; foods, brands and portion sizes to calculate nutrient intakes. Serum HbA1c was measured at recruitment in 11,147 participants (48.7% of cohort). Hazard ratios (HRs) for quintiles of dietary oleic acid intake and serum HbA1c were estimated using Cox regression. Additional analyses were made according to whether body mass index (BMI) was greater or less than 25 kg/m2 as this influences hyperinsulinaemia. RESULTS: 88 participants (55% women) developed PDA after a mean follow-up of 8.4 years (SD = 3.9) (mean age at diagnosis = 72.6 years, SD = 8.8). A decreased risk of PDA was associated with increased dietary oleic acid intake (highest vs lowest quintile, HR = 0.29, 95% CI = 0.10-0.81, P trend across quintiles = 0.011), with statistical significance maintained when BMI>25 kg/m2 but not if BMI<25 kg/m2. An elevated serum HbA1c was associated with increased risk of disease (highest vs lowest quintiles, HR = 6.32, 95% CI = 1.38-28.89, P for trend = 0.004). CONCLUSIONS: The data supports a protective role of oleic acid against development of PDA in those with higher BMIs possibly through influencing hyperinsulinaemia. Oleic acid intake should be accurately measured in future aetiological studies.
dc.formatPrint-Electronic
dc.formatapplication/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.identifier1424-3903
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/280618
dc.identifier10.17863/CAM.27984
dc.identifier1424-3911
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/158997
dc.languageeng
dc.languageeng
dc.publisherElsevier
dc.publisherhttps://doi.org/10.1016/j.pan.2018.07.004
dc.rightsAll rights reserved
dc.rightshttp://purl.org/NET/rdflicense/allrightsreserved
dc.subjectFood diaries
dc.subjectGlycosylated haemoglobin
dc.subjectOleic acid
dc.subjectPancreatic cancer
dc.subjectAdult
dc.subjectAged
dc.subjectBody Mass Index
dc.subjectCarcinoma, Pancreatic Ductal
dc.subjectCohort Studies
dc.subjectDiet
dc.subjectDiet Records
dc.subjectFeeding Behavior
dc.subjectFemale
dc.subjectGlycated Hemoglobin
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOleic Acid
dc.subjectPancreatic Neoplasms
dc.subjectProspective Studies
dc.subjectRisk
dc.subjectRisk Factors
dc.titleDietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study.
dc.typeArticle

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