Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.

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dc.creatorWinder-Rhodes, Sophie E
dc.creatorHampshire, Adam
dc.creatorRowe, James B
dc.creatorPeelle, Jonathan E
dc.creatorRobbins, Trevor W
dc.creatorOwen, Adrian M
dc.creatorBarker, Roger A
dc.date2015-02-18T15:18:21Z
dc.date2015-02-18T15:18:21Z
dc.date2015-03
dc.date.accessioned2026-08-03T01:42:11Z
dc.descriptionGenetic variation is associated with differences in the function of the brain as well as its susceptibility to disease. The common H1 haplotypic variant of the microtubule-associated protein tau gene (MAPT) has been related to an increased risk for Parkinson's disease (PD). Furthermore, among PD patients, H1 homozygotes have an accelerated progression to dementia. We investigated the neurocognitive correlates of MAPT haplotypes using functional magnetic resonance imaging. Thirty-seven nondemented patients with PD (19 H1/H1, 18 H2 carriers) and 40 age-matched controls (21 H1/H1, 19 H2 carriers) were scanned during performance of a picture memory encoding task. Behaviorally, H1 homozygosity was associated with impaired picture recognition memory in PD patients and control subjects. These impairments in the H1 homozygotes were accompanied by an altered blood-oxygen level-dependent response in the medial temporal lobe during successful memory encoding. Additional age-related differences in blood-oxygen level-dependent response were observed in the medial temporal lobes of H1 homozygotes with PD. These results suggest that common variation in MAPT is not only associated with the dementia of PD but also differences in the neural circuitry underlying aspects of cognition in normal aging.
dc.descriptionThis work was funded by Parkinson's UK, the Medical Research Council, the Wellcome Trust (088324), and the NIHR Comprehensive Biomedical Research Centre (RG64473). The BCNI is co-funded by the MRC and Wellcome Trust. Sophie E. Winder-Rhodes received PhD funding from a Merck Sharp and Dohme studentship.
dc.descriptionThis is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.006)
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dc.identifierWinder-Rhodes et al. Neurobiology of Aging (2014) Vol. 36, Issue 3, pp. 1519–1528. DOI:10.1016/j.neurobiolaging.2014.12.006
dc.identifier0197-4580
dc.identifierhttps://www.repository.cam.ac.uk/handle/1810/246876
dc.identifier1558-1497
dc.identifier.urihttps://repo.dare.co.zw/handle/123456789/158140
dc.languageEnglish
dc.languageeng
dc.publisherElsevier
dc.publisherhttps://doi.org/10.1016/j.neurobiolaging.2014.12.006
dc.rightsAttribution 2.0 UK: England & Wales
dc.rightshttps://creativecommons.org/licenses/by/2.0/uk/
dc.subjectAging
dc.subjectCognitive impairment
dc.subjectDementia
dc.subjectGenetics
dc.subjectHippocampus
dc.subjectMAPT
dc.subjectMemory
dc.subjectParkinson's disease
dc.subjectPicture recognition
dc.subjectTau
dc.subjectfMRI
dc.subjectAged
dc.subjectAging
dc.subjectCognition
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectHaplotypes
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMemory
dc.subjectMiddle Aged
dc.subjectOxygen
dc.subjectParkinson Disease
dc.subjectRisk
dc.subjectTemporal Lobe
dc.subjecttau Proteins
dc.titleAssociation between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.
dc.typeArticle

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